End-stage renal disease in Japanese children: a nationwide survey during 2006-2011

Clin Exp Nephrol. 2015 Oct;19(5):933-8. doi: 10.1007/s10157-014-1077-8. Epub 2015 Jan 17.


Background: End-stage renal disease (ESRD) in children is considered a rare, but serious condition. Epidemiological and demographic information on pediatric ESRD patients around the world is important to better understand this disease and to improve patient care. The Japanese Society for Pediatric Nephrology (JSPN) reported epidemiological and demographic data in 1998. Since then, however, there has been no nationwide survey on Japanese children with ESRD.

Methods: The JSPN conducted a cross-sectional nationwide survey in 2012 to update information on the incidence, primary renal disease, initial treatment modalities, and survival in pediatric Japanese patients with ESRD aged less than 20 years during the period 2006-2011.

Results: The average incidence of ESRD was 4.0 per million age-related population. Congenital anomalies of the kidney and urinary tract were the most common cause of ESRD, present in 39.8 % of these patients. In addition, 12.2 % had focal segmental glomerulosclerosis and 5.9 % had glomerulonephritis. Initial treatment modalities in patients who commenced renal replacement therapy (RRT) consisted of peritoneal dialysis, hemodialysis, and pre-emptive transplantation (Tx) in 61.7, 16.0, and 22.3 %, respectively. The Japanese RRT mortality rate was 18.2 deaths per 1000 person-years of observation.

Conclusion: The incidence of ESRD is lower in Japanese children than in children of other high-income countries. Since 1998, notably, there has been a marked increase in pre-emptive Tx as an initial treatment modality for Japanese children with ESRD.

Keywords: Children; End-stage renal disease; Epidemiology; Japan; Renal replacement therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Asian Continental Ancestry Group
  • Cause of Death
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Female
  • Glomerulosclerosis, Focal Segmental / epidemiology
  • Health Surveys
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Japan / epidemiology
  • Kidney / abnormalities
  • Kidney Failure, Chronic / epidemiology*
  • Kidney Failure, Chronic / etiology
  • Kidney Failure, Chronic / mortality
  • Kidney Transplantation / statistics & numerical data
  • Male
  • Peritoneal Dialysis / statistics & numerical data
  • Renal Dialysis / statistics & numerical data
  • Renal Replacement Therapy
  • Survival Analysis
  • Urinary Tract / abnormalities
  • Young Adult