Declining relative risk for myocardial infarction among HIV-positive compared with HIV-negative individuals with access to care

Daniel B Klein; Wendy A Leyden; Lanfang Xu; Chun R Chao; Michael A Horberg; William J Towner; Leo B Hurley; Julia L Marcus; Charles P Quesenberry Jr; Michael J Silverberg

doi:10.1093/cid/civ014

Declining relative risk for myocardial infarction among HIV-positive compared with HIV-negative individuals with access to care

Clin Infect Dis. 2015 Apr 15;60(8):1278-80. doi: 10.1093/cid/civ014. Epub 2015 Jan 16.

Affiliations

¹ Division of Infectious Diseases, Department of Internal Medicine, Kaiser Permanente, San Leandro.
² Division of Research, Kaiser Permanente, Oakland.
³ Department of Research and Evaluation, Kaiser Permanente, Pasadena, California.
⁴ Mid-Atlantic Permanente Research Institute, Rockville, Maryland.
⁵ Division of Infectious Diseases, Department of Internal Medicine, Kaiser Permanente, Los Angeles, California.

PMID: 25595743
DOI: 10.1093/cid/civ014

Abstract

Concerns remain for an increased myocardial infarction (MI) risk among individuals infected with human immunodeficiency virus (HIV). We conducted a cohort study evaluating MI risk from 1996 to 2011 by HIV status. The adjusted MI rate ratio for HIV status declined over time, reaching 1.0 (95% confidence interval, .7-1.4) in 2010-2011, the most recent study period.

Keywords: HIV; myocardial infarction; secular trend.

Publication types

Clinical Study
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Cohort Studies
Female
HIV Infections / complications*
Humans
Male
Middle Aged
Myocardial Infarction / epidemiology*
Risk
Young Adult