Vulvo-vaginal atrophy: a new treatment modality using thermo-ablative fractional CO2 laser

Maturitas. 2015 Mar;80(3):296-301. doi: 10.1016/j.maturitas.2014.12.006. Epub 2014 Dec 25.


Objective: To evaluate the efficacy and feasibility of thermo-ablative fractional CO2 laser for the treatment of symptoms related to vulvo-vaginal atrophy (VVA) in post-menopausal women.

Methods: From April 2013 to December 2013, post-menopausal patients who complained of one or more VVA-related symptoms and who underwent vaginal treatment with fractional CO2 laser were enrolled in the study. At baseline (T0) and 30 days post-treatment (T1), vaginal status of the women was evaluated using the Vaginal Health Index (VHI), and subjective intensity of VVA symptoms was evaluated using a visual analog scale (VAS). At T1, treatment satisfaction was evaluated using a 5-point Likert scale.

Results: During the study period, a total of 48 patients were enrolled. Data indicated a significant improvement in VVA symptoms (vaginal dryness, burning, itching and dyspareunia) (P<0.0001) in patients who had undergone 3 sessions of vaginal fractional CO2 laser treatment. Moreover, VHI scores were significantly higher at T1 (P<0.0001). Overall, 91.7% of patients were satisfied or very satisfied with the procedure and experienced considerable improvement in quality of life (QoL). No adverse events due to fractional CO2 laser treatment occurred.

Conclusion: Thermo-ablative fractional CO2 laser could be a safe, effective and feasible option for the treatment of VVA symptoms in post-menopausal women.

Keywords: Laser treatment; Menopause; Vulvo-vaginal atrophy.

Publication types

  • Observational Study

MeSH terms

  • Administration, Intravaginal
  • Atrophy / therapy
  • Dyspareunia / surgery*
  • Female
  • Humans
  • Laser Therapy
  • Lasers, Gas / therapeutic use*
  • Middle Aged
  • Pilot Projects
  • Postmenopause*
  • Quality of Life
  • Treatment Outcome
  • Vaginal Diseases / surgery*
  • Vulva / pathology*