Suppression of antigen presentation by IL-10

Curr Opin Immunol. 2015 Jun;34:22-7. doi: 10.1016/j.coi.2014.12.009. Epub 2015 Jan 16.

Abstract

Regulated antigen presentation to immune cells determines the effectiveness of an immune response. IL-10 is an immunosuppressive cytokine that regulates immune responses by inhibiting the ability of APCs to present antigens to T cells in a variety of ways. The mechanisms of IL-10-mediated immunosuppression include interference in TLR-mediated or IFNγ-mediated dendritic cell (DC) and macrophage activation as well as direct induction of genes that suppress APC function. In this review we will discuss current studies exploring the molecular mechanisms by which IL-10 suppresses APC function.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Antigen Presentation*
  • Dendritic Cells / immunology
  • Humans
  • Immune Tolerance
  • Interleukin-10 / immunology*
  • Phagocytes / immunology
  • Signal Transduction
  • Toll-Like Receptors / immunology

Substances

  • Toll-Like Receptors
  • Interleukin-10