Thirty years of intracrinology

Ochsner J. 2014 Winter;14(4):673-80.


Background: Intracrinology is the study of the intracellular actions, regulation, trafficking, and interactions of extracellular signaling peptides/proteins.

Methods: We describe the development of intracrine biology since the term was defined in 1984.

Results: Intracrine biology plays a role in many normal and pathological processes and represents a fertile field for the development of novel therapeutics.

Conclusion: Although 30 years old, the field of intracrinology is only now becoming widely accepted. Intracrine principles can be applied to the investigation of physiological processes and to the development of new therapies.

Keywords: Angiotensin II; cytoplasmic and nuclear receptors; intracellular signaling peptides and proteins; intracrine; intracrinology; renin-angiotensin systems.

Publication types

  • Review