Is rosuvastatin protective against on noise-induced oxidative stress in rat serum?

Noise Health. Jan-Feb 2015;17(74):11-6. doi: 10.4103/1463-1741.149565.

Abstract

Noise, one of the main components of modern society, has become an important environmental problem. Noise is not only an irritating sound, but also a stress factor leading to serious health problems. In this study, we have investigated possible effects of rosuvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, thought to have an antioxidant effect, on noise-induced oxidative stress in the serum of rat models. Thirty-two male Wistar albino rats were used. In order to ease their adaptation, 2 weeks before the experiment, the rats were divided into four groups (with eight rats per each group): Noise exposure plus rosuvastatin usage, only noise exposure, only rosuvastatin usage and control. After the data had been collected, oxidant (Malondialdehyde, nitric oxide [NO], protein carbonyl [PC]) and antioxidant (superoxide dismutase [SOD], glutathione peroxidase [GSH-PX], catalase [CAT]) parameters were analyzed in the serum. Results indicated that SOD values were found to be significantly lower, while PC values in serum were remarkably higher in the group that was exposed to only noise. GSH-Px values in serum dramatically increased in the group on which only rosuvastatin was used. During noise exposure, the use of rosuvastatin caused significantly increased CAT values, whereas it resulted in reduced PC and NO values in serum. In conclusion, our data show that noise exposure leads to oxidative stress in rat serum; however, rosuvastatin therapy decreases the oxidative stress caused by noise exposure.

MeSH terms

  • Animals
  • Antioxidants / analysis
  • Antioxidants / pharmacology*
  • Fluorobenzenes / pharmacology*
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
  • Male
  • Noise / adverse effects*
  • Oxidants / blood*
  • Oxidative Stress / drug effects*
  • Oxidative Stress / physiology
  • Pyrimidines / pharmacology*
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Rosuvastatin Calcium
  • Sulfonamides / pharmacology*

Substances

  • Antioxidants
  • Fluorobenzenes
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Oxidants
  • Pyrimidines
  • Sulfonamides
  • Rosuvastatin Calcium