Children with atopic dermatitis show clinical improvement after Lactobacillus exposure

Clin Exp Allergy. 2015 Apr;45(4):779-87. doi: 10.1111/cea.12489.


Background: The role of probiotics in the treatment of atopic dermatitis (AD) is not clearly established. Further clinical trials with new probiotic formulations are warranted.

Objectives: To assess the effects of Lactobacillus paracasei (LP) and Lactobacillus fermentum (LF), and their mixture on the disease severity, quality of life, and immune biomarkers of children with AD.

Method: A double-blind, prospective, randomized placebo-controlled study was conducted on 220 children aged 1-18 years with moderate-to-severe AD (Trial number: NCT01635738). The children were randomized to receive LP, LF, LP + LF mixture, and placebo for 3 months. Changes in severity scoring of atopic dermatitis (SCORAD), Family Dermatology Life Quality Index (FDLQI), and Children's Dermatology Life Quality Index (CDLQI) scores in the different groups and at different visits were evaluated. Skin prick tests, levels of IgE, IFN-γ, IL-4, TGF-β, and TNF-α, and urine biomarkers were also evaluated.

Results: Children who received LP, LF, and LP + LF mixture showed lower SCORAD scores than the placebo group (P < 0.001), and this difference remained even at 4 months after discontinuing the probiotics. The FDLQI and CDLQI scores were lower in the LP, LF, and LP + LF mixture group than in the placebo group (P = 0.02 and 0.03). IgE, TNF-α, urine eosinophilic protein X, and 8-OHdG levels decreased, whereas IFN-γ and TGF-β increased in the probiotic groups, but these did not reach statistical significance except for IL-4 (P = 0.04). In subgroup analyses, SCORAD scores significantly decreased after probiotic treatment especially in children younger than age 12, with breastfeeding > 6 months, and with mite sensitization (P < 0.001).

Conclusion: Supplementation of a probiotic mixture of LP and LF is associated with clinical improvement in children with AD.

Keywords: SCORAD score; atopic dermatitis; clinical trial; probiotics.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Cytokines / blood
  • Cytokines / metabolism
  • Dermatitis, Atopic / diagnosis
  • Dermatitis, Atopic / immunology*
  • Dermatitis, Atopic / therapy*
  • Female
  • Humans
  • Immunization
  • Immunoglobulin E / blood
  • Immunoglobulin E / immunology
  • Infant
  • Lactobacillus / immunology*
  • Male
  • Probiotics / adverse effects
  • Probiotics / therapeutic use*
  • Quality of Life
  • Severity of Illness Index
  • Treatment Outcome


  • Cytokines
  • Immunoglobulin E

Associated data