Targeting T cell metabolism for therapy

Trends Immunol. 2015 Feb;36(2):71-80. doi: 10.1016/j.it.2014.12.004. Epub 2015 Jan 15.

Abstract

In the past several years a wealth of evidence has emerged illustrating how metabolism supports many aspects of T cell biology, as well as how metabolic changes drive T cell differentiation and fate. We outline developing principles in the regulation of T cell metabolism, and discuss how these processes are affected in settings of inflammation and cancer. In this context we discuss how metabolic pathways might be manipulated for the treatment of human disease, including how metabolism may be targeted to prevent T cell dysfunction in inhospitable microenvironments, to generate more effective adoptive cellular immunotherapies in cancer, and to direct T cell differentiation and function towards non-pathogenic phenotypes in settings of autoimmunity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / metabolism
  • Autoimmune Diseases / therapy
  • Cellular Microenvironment / genetics
  • Cellular Microenvironment / immunology
  • Humans
  • Immunotherapy, Adoptive*
  • Neoplasms / immunology
  • Neoplasms / metabolism
  • Neoplasms / therapy
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocyte Subsets / metabolism*