Effects of systemic hypoxia on human muscular adaptations to resistance exercise training

doi:10.14814/phy2.12267

. 2015 Jan 19;3(1):e12267.

doi: 10.14814/phy2.12267. Print 2015 Jan 1.

Effects of systemic hypoxia on human muscular adaptations to resistance exercise training

Michihiro Kon¹, Nao Ohiwa², Akiko Honda², Takeo Matsubayashi², Tatsuaki Ikeda², Takayuki Akimoto³, Yasuhiro Suzuki², Yuichi Hirano², Aaron P Russell⁴

Affiliations

¹ Department of Sports Sciences, Japan Institute of Sports Sciences, 3-15-1 Nishigaoka, Kita, Tokyo, Japan Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia.
² Department of Sports Sciences, Japan Institute of Sports Sciences, 3-15-1 Nishigaoka, Kita, Tokyo, Japan.
³ Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, Japan.
⁴ Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia.

PMID: 25602020
PMCID: PMC4387762
DOI: 10.14814/phy2.12267

Free PMC article

Effects of systemic hypoxia on human muscular adaptations to resistance exercise training

Michihiro Kon et al. Physiol Rep. 2015.

Free PMC article

. 2015 Jan 19;3(1):e12267.

doi: 10.14814/phy2.12267. Print 2015 Jan 1.

Authors

Michihiro Kon¹, Nao Ohiwa², Akiko Honda², Takeo Matsubayashi², Tatsuaki Ikeda², Takayuki Akimoto³, Yasuhiro Suzuki², Yuichi Hirano², Aaron P Russell⁴

Affiliations

¹ Department of Sports Sciences, Japan Institute of Sports Sciences, 3-15-1 Nishigaoka, Kita, Tokyo, Japan Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia.
² Department of Sports Sciences, Japan Institute of Sports Sciences, 3-15-1 Nishigaoka, Kita, Tokyo, Japan.
³ Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, Japan.
⁴ Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia.

PMID: 25602020
PMCID: PMC4387762
DOI: 10.14814/phy2.12267

Abstract

This study investigated the effect of resistance exercise training performed under systemic hypoxia or normoxia on biochemical and molecular muscular adaptations in healthy male subjects. Our findings demonstrate that resistance training under systemic hypoxia led not only to muscle hypertrophy, but most interestingly, to a greater increase in muscular endurance. This increase in muscular endurance was potentially caused by the increased angiogenesis as determined by capillary‐to‐fiber ratio.

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References

1. Álvarez‐Herms J., Sonia J., Francisco C., Teresa P., Ginés V. 2012. Changes in heart rate recovery index after a programme of strength/endurance training in hypoxia. Apunts Medicina de l'Esport.; 47:23-29.
1. Kon M., Ohiwa N., Honda A., Matsubayashi T., Ikeda T., Akimoto T. 2014. Effects of systemic hypoxia on human muscular adaptations to resistance exercise training. Physiol. Rep.; 6:e12033. - PMC - PubMed
1. Manimmanakorn A., Hamlin M. J., Ross J. J., Taylor R., Manimmanakorn N. 2013. Effects of low‐load resistance training combined with blood flow restriction or hypoxia on muscle function and performance in netball athletes. J. Sci. Med. Sport; 16:337-342. - PubMed

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[1] Álvarez‐Herms J., Sonia J., Francisco C., Teresa P., Ginés V. 2012. Changes in heart rate recovery index after a programme of strength/endurance training in hypoxia. Apunts Medicina de l'Esport.; 47:23-29.

[2] Álvarez‐Herms J., Sonia J., Francisco C., Teresa P., Ginés V. 2012. Changes in heart rate recovery index after a programme of strength/endurance training in hypoxia. Apunts Medicina de l'Esport.; 47:23-29.

[3] Kon M., Ohiwa N., Honda A., Matsubayashi T., Ikeda T., Akimoto T. 2014. Effects of systemic hypoxia on human muscular adaptations to resistance exercise training. Physiol. Rep.; 6:e12033. - PMC - PubMed

[4] Kon M., Ohiwa N., Honda A., Matsubayashi T., Ikeda T., Akimoto T. 2014. Effects of systemic hypoxia on human muscular adaptations to resistance exercise training. Physiol. Rep.; 6:e12033. - PMC - PubMed

[5] Manimmanakorn A., Hamlin M. J., Ross J. J., Taylor R., Manimmanakorn N. 2013. Effects of low‐load resistance training combined with blood flow restriction or hypoxia on muscle function and performance in netball athletes. J. Sci. Med. Sport; 16:337-342. - PubMed

[6] Manimmanakorn A., Hamlin M. J., Ross J. J., Taylor R., Manimmanakorn N. 2013. Effects of low‐load resistance training combined with blood flow restriction or hypoxia on muscle function and performance in netball athletes. J. Sci. Med. Sport; 16:337-342. - PubMed

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Effects of systemic hypoxia on human muscular adaptations to resistance exercise training

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Effects of systemic hypoxia on human muscular adaptations to resistance exercise training

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