Invasive adenylate cyclase toxin of Bordetella pertussis

Trends Biochem Sci. 1989 Nov;14(11):459-63. doi: 10.1016/0968-0004(89)90106-0.

Abstract

Bordetella pertussis produces an adenylate cyclase which is a toxin. The enzyme penetrates eukaryotic cells and, upon activation by host calmodulin, generates high levels of intracellular cAMP; as a result bactericidal functions of immune effector cells are considerably impaired. The toxin is composed of a single polypeptide that possesses both the catalytic and the toxic functions. It penetrates the host cell directly from the plasma membrane and is concomitantly inactivated by a proteolytic degradation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Adenylate Cyclase Toxin*
  • Adenylyl Cyclases / isolation & purification
  • Adenylyl Cyclases / metabolism*
  • Adenylyl Cyclases / toxicity
  • Animals
  • Bordetella pertussis / enzymology*
  • Calcium / physiology
  • Calmodulin / metabolism
  • Cyclic AMP / biosynthesis
  • Enzyme Activation
  • Genes, Bacterial
  • Humans
  • Virulence Factors, Bordetella / isolation & purification
  • Virulence Factors, Bordetella / metabolism*
  • Virulence Factors, Bordetella / toxicity

Substances

  • Adenylate Cyclase Toxin
  • Calmodulin
  • Virulence Factors, Bordetella
  • Cyclic AMP
  • Adenylyl Cyclases
  • Calcium