Asparagus polysaccharide and gum with hepatic artery embolization induces tumor growth and inhibits angiogenesis in an orthotopic hepatocellular carcinoma model

Asian Pac J Cancer Prev. 2014;15(24):10949-55. doi: 10.7314/apjcp.2014.15.24.10949.


Liver cancer is one of leading digestive malignancies with high morbidity and mortality. There is an urgent need for the development of novel therapies for this deadly disease. It has been proven that asparagus polysaccharide, one of the most active derivates from the traditional medicine asparagus, possesses notable antitumor properties. However, little is known about the efficacy of asparagus polysaccharide as an adjuvant for liver cancer chemotherapy. Herein, we reported that asparagus polysaccharide and its embolic agent form, asparagus gum, significantly inhibited liver tumor growth with transcatheter arterial chemoembolization (TACE) therapy in an orthotopic hepatocellular carcinoma (HCC) tumor model, while significantly inhibiting angiogenesis and promoting tumor cell apoptosis. Moreover, asparagine gelatinous possessed immunomodulatory functions and showed little toxicity to the host. These results highlight the chemotherapeutic potential of asparagus polysaccharide and warrant a future focus on development as novel chemotherapeutic agent for liver cancer TACE therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Asparagus Plant / chemistry*
  • Blotting, Western
  • Carcinoma 256, Walker / blood supply
  • Carcinoma 256, Walker / mortality
  • Carcinoma 256, Walker / pathology
  • Carcinoma 256, Walker / prevention & control
  • Carcinoma, Hepatocellular / blood supply
  • Carcinoma, Hepatocellular / mortality
  • Carcinoma, Hepatocellular / pathology*
  • Carcinoma, Hepatocellular / prevention & control*
  • Chemoembolization, Therapeutic*
  • Hepatic Artery / drug effects*
  • Hepatic Artery / pathology
  • Humans
  • Liver Neoplasms / blood supply
  • Liver Neoplasms / mortality
  • Liver Neoplasms / pathology
  • Liver Neoplasms / prevention & control
  • Male
  • Neovascularization, Pathologic / prevention & control*
  • Polysaccharides / pharmacology*
  • Rats
  • Rats, Wistar
  • Survival Rate
  • Tumor Cells, Cultured
  • Xenograft Model Antitumor Assays


  • Polysaccharides