Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) carrying the mecC gene (mecC-MRSA) exhibited at 37°C MICs of oxacillin close to those of methicillin-susceptible S. aureus (MSSA). We investigated whether at this temperature, mecC-MRSA strains respond to flucloxacillin treatment like MSSA strains, using a rat model of endocarditis. Flucloxacillin (human-like kinetics of 2 g intravenously every 6 h) cured 80 to 100% of aortic vegetations infected with five different mecC-MRSA strains. These results suggest that mecC-MRSA infections may successfully respond to treatment with β-lactams.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / therapeutic use*
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Aorta / microbiology
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Cefoxitin / pharmacology
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Chromatography, Micellar Electrokinetic Capillary
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Endocarditis, Bacterial / drug therapy*
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Endocarditis, Bacterial / microbiology
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Floxacillin / administration & dosage
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Floxacillin / therapeutic use*
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Infusion Pumps
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Methicillin-Resistant Staphylococcus aureus / genetics*
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Microbial Sensitivity Tests
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Oxacillin / pharmacology
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Rats
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / microbiology
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Temperature
Substances
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Anti-Bacterial Agents
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Floxacillin
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Cefoxitin
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Oxacillin