Taking T cell priming down a Notch: signaling through Notch receptors enhances T cell sensitivity to antigen

Immunity. 2015 Jan 20;42(1):6-8. doi: 10.1016/j.immuni.2014.12.026.


Notch receptors are widely expressed and have recognized functions in thymocytes and mature T cells. In this issue, Laky et al. (2015) show that Notch interactions with Delta-like ligand 4 (DLL4) amplify priming of naive T cells.

Publication types

  • Comment

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology*
  • Carcinoma / immunology*
  • Female
  • Male
  • Receptor Cross-Talk*
  • Receptors, Notch / metabolism*
  • Signal Transduction*


  • Receptors, Notch