Evaluation of efficacy and tolerance of a nighttime topical antioxidant containing resveratrol, baicalin, and vitamin e for treatment of mild to moderately photodamaged skin

J Drugs Dermatol. 2014 Dec;13(12):1467-72.


Resveratrol is an effective anti-aging molecule with diverse biologic activity. It functions as a dual antioxidant that can neutralize free radicals and increase intrinsic antioxidant capacity. Additionally resveratrol increases mitochondrial biogenesis and has anti-inflammatory, anti-diabetic, and anti-cancer activity. In this paper we will focus on the use of topically applied resveratrol using a proprietary blend containing 1% resveratrol, 0.5% baicalin, and 1% vitamin E. This stabilized high concentration formulation demonstrates percutaneous absorption and alterations in gene expression such as hemoxygenase-1 (HO-1), vascular endothelial growth factor (VEGFA), and collagen 3 (COL3A1). Clinical assessment showed a statistically significant improvement in fine lines and wrinkles, skin firmness, skin elasticity, skin laxity, hyperpigmentation, radiance, and skin roughness over baseline in 12 weeks. Ultrasound measurements in the periorbital area showed an average improvement of 18.9% in dermal thickness suggesting significant dermal remodeling. These studies confirm that topical resveratrol, baicalin, and vitamin E are valuable ingredient that can be used for skin rejuvenation.

Publication types

  • Clinical Trial

MeSH terms

  • Administration, Cutaneous
  • Adult
  • Antioxidants / administration & dosage
  • Antioxidants / adverse effects
  • Antioxidants / therapeutic use*
  • Cosmetic Techniques* / adverse effects
  • Drug Combinations
  • Female
  • Flavonoids / administration & dosage
  • Flavonoids / adverse effects
  • Flavonoids / therapeutic use
  • Gene Expression Regulation / drug effects
  • Humans
  • Hyperpigmentation / drug therapy*
  • Middle Aged
  • Prospective Studies
  • Rejuvenation
  • Resveratrol
  • Skin Absorption
  • Skin Aging / drug effects*
  • Stilbenes / administration & dosage
  • Stilbenes / adverse effects
  • Stilbenes / therapeutic use
  • Vitamin E / administration & dosage
  • Vitamin E / adverse effects
  • Vitamin E / therapeutic use


  • Antioxidants
  • Drug Combinations
  • Flavonoids
  • Stilbenes
  • Vitamin E
  • baicalin
  • Resveratrol