Clinical characteristics of adults with chronic rhinosinusitis and specific antibody deficiency

J Allergy Clin Immunol Pract. Mar-Apr 2015;3(2):236-42. doi: 10.1016/j.jaip.2014.09.022. Epub 2014 Nov 25.


Background: Specific antibody deficiency (SAD) involves a deficient response to a polysaccharide vaccine in the setting of normal immunoglobulin G (IgG) levels and chronic infections. Patients with chronic rhinosinusitis (CRS) are often evaluated for SAD. There are limited data that describe patients with CRS and SAD.

Objective: The objective of this study was to better characterize the role of SAD in CRS.

Methods: We reviewed electronic records of adults with CRS who were evaluated for immunodeficiency with quantitative Ig levels and pre- and postantibody titers to a pneumococcal polysaccharide vaccine (PPV).

Results: Fourteen pneumococcal serotypes were determined in 239 subjects from 2002 to 2009. Of these subjects, 64 had adequate protective titers of 1.3 μg/mL or higher in 7 or more serotypes of the 14 serotypes checked; 56 (23%) had less than 7 protective titers post-PPV and were diagnosed with SAD; and 119 had an adequate response to the vaccine with 7 or more serotypes being higher than 1.3 μg/mL (>50% response) and were characterized as "responders." Subjects with SAD received more antibiotic courses relative to responders in the 2 years after immunization (3.19 ± 2.64 vs 2.19 ± 2.24, P < .05). Of 56 subjects with SAD, 10 (17.9%) received Ig replacement therapy. Subjects who received Ig had fewer numbers of protective pneumococcal titers post-PPV and had more pneumonia (40.0%) versus subjects with SAD who did not receive Ig (10.9%).

Conclusions: Of the 239 patients with CRS with normal IgG levels evaluated for immunodeficiency, 56 (23.4%) had SAD. A majority of patients with SAD may not need Ig replacement; however, a subset of patients with SAD benefit from Ig replacement.

Keywords: Chronic rhinosinusitis; Immunoglobulin replacement therapy; Pneumococcal antibody concentration; Primary immunodeficiency; Specific antibody deficiency.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antibodies, Bacterial / blood
  • Chronic Disease
  • Female
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulins / therapeutic use
  • Immunologic Deficiency Syndromes* / blood
  • Immunologic Deficiency Syndromes* / diagnosis
  • Immunologic Deficiency Syndromes* / drug therapy
  • Male
  • Middle Aged
  • Pneumococcal Vaccines
  • Rhinitis* / blood
  • Rhinitis* / diagnosis
  • Rhinitis* / drug therapy
  • Serogroup
  • Sinusitis* / blood
  • Sinusitis* / diagnosis
  • Sinusitis* / drug therapy
  • Streptococcus pneumoniae / immunology


  • Antibodies, Bacterial
  • Immunoglobulin G
  • Immunoglobulins
  • Pneumococcal Vaccines