Characterization of a mammalian prosencephalic functional plan

Front Neuroanat. 2015 Jan 6;8:161. doi: 10.3389/fnana.2014.00161. eCollection 2014.

Abstract

Hypothalamic organizational concepts have greatly evolved as the primary hypothalamic pathways have been systematically investigated. In the present review, we describe how the hypothalamus arises from a molecularly heterogeneous region of the embryonic neural tube but is first differentiated as a primary neuronal cell cord (earliest mantle layer). This structure defines two axes that align onto two fundamental components: a longitudinal tractus postopticus(tpoc)/retinian component and a transverse supraoptic tract(sot)/olfactory component. We then discuss how these two axonal tracts guide the formation of all major tracts that connect the telencephalon with the hypothalamus/ventral midbrain, highlighting the existence of an early basic plan in the functional organization of the prosencephalic connectome.

Keywords: cell cord; lateral hypothalamic area; medial forebrain bundle; melanin concentrating hormone; pioneer tracts.

Publication types

  • Review