Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion

Oncoimmunology. 2014 Jul 3;3(7):e947871. doi: 10.4161/21624011.2014.947871. eCollection 2014.


Tumor cells undergo molecular evolution under immune pressure. Using a murine metastatic lung cancer model, we recently reported that evolutionary pressure enforced through vaccination incites gain of Nanog, a master transcription factor that mediates both emergence of a stem-like cancer cell state and immune evasion. Thus, therapeutic strategies aiming to blunt NANOG's expression in patient tumors may improve the clinical management of cancer.

Keywords: Nanog; cytotoxic T lymphocytes; immune surveillance; immune-resistant; stem-like phenotype.

Publication types

  • Research Support, Non-U.S. Gov't