Striking the right balance: cortical modulation of the subthalamic nucleus-globus pallidus circuit

Kevin J Mastro; Aryn H Gittis

doi:10.1016/j.neuron.2014.12.062

Striking the right balance: cortical modulation of the subthalamic nucleus-globus pallidus circuit

Neuron. 2015 Jan 21;85(2):233-5. doi: 10.1016/j.neuron.2014.12.062.

Authors

Kevin J Mastro¹, Aryn H Gittis²

Affiliations

¹ Center of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA; Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
² Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA 15213, USA. Electronic address: agittis@cmu.edu.

PMID: 25611504
DOI: 10.1016/j.neuron.2014.12.062

Abstract

The subthalamic nucleus-globus pallidus network is a potential source of oscillations in Parkinson's disease, but the mechanism is unknown. In this issue of Neuron, Chu et al. (2015) present a cortically driven form of heterosynaptic plasticity that could promote oscillatory activity after dopamine depletion.

Publication types

Comment

MeSH terms

Animals
Dopamine / metabolism*
Globus Pallidus / metabolism*
Glutamic Acid / metabolism*
Motor Cortex / metabolism*
Neural Pathways / metabolism*
Parkinsonian Disorders / metabolism*
Subthalamic Nucleus / metabolism*
gamma-Aminobutyric Acid / metabolism*

Substances

Glutamic Acid
gamma-Aminobutyric Acid
Dopamine