Comparison of an oscillometric method with cardiac magnetic resonance for the analysis of aortic pulse wave velocity

PLoS One. 2015 Jan 22;10(1):e0116862. doi: 10.1371/journal.pone.0116862. eCollection 2015.

Abstract

Objectives: Pulse wave velocity (PWV) is the proposed gold-standard for the assessment of aortic elastic properties. The aim of this study was to compare aortic PWV determined by a recently developed oscillometric device with cardiac magnetic resonance imaging (CMR).

Methods: PWV was assessed in 40 volunteers with two different methods. The oscillometric method (PWVOSC) is based on a transfer function from the brachial pressure waves determined by oscillometric blood pressure measurements with a common cuff (Mobil-O-Graph, I.E.M. Stolberg, Germany). CMR was used to determine aortic PWVCMR with the use of the transit time method based on phase-contrast imaging at the level of the ascending and abdominal aorta on a clinical 1.5 Tesla scanner (Siemens, Erlangen, Germany).

Results: The median age of the study population was 34 years (IQR: 24-55 years, 11 females). A very strong correlation was found between PWVOSC and PWVCMR (r = 0.859, p < 0.001). Mean PWVOSC was 6.7 ± 1.8 m/s and mean PWVCMR was 6.1 ± 1.8 m/s (p < 0.001). Analysis of agreement between the two measurements using Bland-Altman method showed a bias of 0.57 m/s (upper and lower limit of agreement: 2.49 m/s and -1.34 m/s). The corresponding coefficient of variation between both measurements was 15%.

Conclusion: Aortic pulse wave velocity assessed by transformation of the brachial pressure waveform showed an acceptable agreement with the CMR-derived transit time method.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aorta / physiopathology*
  • Aortography / methods
  • Elasticity Imaging Techniques / methods*
  • Humans
  • Image Processing, Computer-Assisted*
  • Magnetic Resonance Angiography / methods*
  • Male
  • Middle Aged
  • Pulse Wave Analysis*

Grant support

This study was supported by grants from the Austrian Society of Cardiology and by a grant from the Innsbruck Medical University (MUI-START) (#2013042016) to Gert Klug, Sebastian J Reinstadler, and Bernhard Metzler. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.