The Mediating Role of Resilience on Quality of Life and Cancer Symptom Distress in Adolescent Patients With Cancer

J Pediatr Oncol Nurs. Sep-Oct 2015;32(5):304-13. doi: 10.1177/1043454214563758. Epub 2015 Jan 22.


Understanding how cancer symptom distress and resilience contribute to quality of life (QoL) in adolescent cancer and may potentially help these patients achieve better health-related outcomes. The objective of this study was to describe cancer symptom distress, QoL, and resilience in adolescents with cancer and to determine whether resilience is a mediating variable. Forty adolescent cancer patients were recruited, and data were collected via a demographic questionnaire, the Cancer Symptom Distress Scale, the Resilience Scale, and the Minneapolis-Manchester Quality of Life Scale. Pearson's correlation, multiple regressions, and the Sobel test were conducted. Both resilience and cancer symptom distress were regressed against QoL, accounting for 62.1% of observed variation in QoL scores. The bootstrap result estimated the true indirect effect between -.0189 and -.0024, with a 95% confidence interval. Resilience mediates the relationship between cancer symptom distress and QoL. Clinical use of a resilience measure, for example to use in developing and evaluating interventions focused on enhancing resilience, may be practical for nurses.

Keywords: adolescent; cancer symptom; mediating effect; quality of life; resilience.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adolescent Health Services
  • Female
  • Humans
  • Male
  • Neoplasms / nursing*
  • Neoplasms / psychology
  • Oncology Nursing
  • Pediatric Nursing
  • Quality of Life*
  • Resilience, Psychological*
  • Stress, Psychological*
  • Surveys and Questionnaires
  • Young Adult