Monocarboxylate transporters: new players in body weight regulation

Obes Rev. 2015 Feb:16 Suppl 1:55-66. doi: 10.1111/obr.12256.


Over the last two decades, several genes have been identified that appear to play a role in the regulation of energy homeostasis and body weight. For a small subset of them, a reduction or an absence of expression confers a resistance to the development of obesity. Recently, a knockin mouse for a member of the monocarboxylate transporter (MCT) family, MCT1, was demonstrated to exhibit a typical phenotype of resistance to diet-induced obesity and a protection from its associated metabolic perturbations. Such findings point out at MCTs as putatively new therapeutic targets in the context of obesity. Here, we will review what is known about MCTs and their possible metabolic roles in different organs and tissues. Based on the description of the phenotype of the MCT1 knockin mouse, we will also provide some insights about their putative roles in weight gain regulation.

Keywords: Brain energetics; monocarboxylate transporter; obesity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Body Composition / genetics*
  • Carrier Proteins / metabolism
  • Disease Models, Animal
  • Gene Expression Regulation
  • Homeostasis
  • Humans
  • Metabolic Networks and Pathways
  • Mice
  • Mice, Knockout
  • Mice, Mutant Strains
  • Monocarboxylic Acid Transporters / metabolism*
  • Obesity / genetics
  • Obesity / metabolism*
  • Organ Specificity
  • Weight Gain*
  • Weight Loss*


  • Carrier Proteins
  • Monocarboxylic Acid Transporters