The detection of epileptic seizure signals based on fuzzy entropy

Abstract

Background: Entropy is a nonlinear index that can reflect the degree of chaos within a system. It is often used to analyze epileptic electroencephalograms (EEG) to detect whether there is an epileptic attack. Much research into the state inspection of epileptic seizures has been conducted based on sample entropy (SampEn). However, the study of epileptic seizures based on fuzzy entropy (FuzzyEn) has lagged behind.

New methods: We propose a method of state inspection of epileptic seizures based on FuzzyEn. The method first calculates the FuzzyEn of EEG signals from different epileptic states, and then feature selection is conducted to obtain classification features. Finally, we use the acquired classification features and a grid optimization method to train support vector machines (SVM).

Results: The results of two open-EEG datasets in epileptics show that there are major differences between seizure attacks and non-seizure attacks, such that FuzzyEn can be used to detect epilepsy, and our method obtains better classification performance (accuracy, sensitivity and specificity of classification of the CHB-MIT are 98.31%, 98.27% and 98.36%, and of the Bonn are 100%, 100%, 100%, respectively).

Comparisons with existing method(s): To verify the performance of the proposed method, a comparison of the classification performance for epileptic seizures using FuzzyEn and SampEn is conducted. Our method obtains better classification performance, which is superior to the SampEn-based methods currently in use.

Conclusions: The results indicate that FuzzyEn is a better index for detecting epileptic seizures effectively. The FuzzyEn-based method is preferable, exhibiting potential desirable applications for medical treatment.

Keywords: Epilepsy detection; Fuzzy entropy; SVM; Sample entropy.