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, 5 (1), 269-93

Terpenoids and Their Biosynthesis in Cyanobacteria


Terpenoids and Their Biosynthesis in Cyanobacteria

Bagmi Pattanaik et al. Life (Basel).


Terpenoids, or isoprenoids, are a family of compounds with great structural diversity which are essential for all living organisms. In cyanobacteria, they are synthesized from the methylerythritol-phosphate (MEP) pathway, using glyceraldehyde 3-phosphate and pyruvate produced by photosynthesis as substrates. The products of the MEP pathway are the isomeric five-carbon compounds isopentenyl diphosphate and dimethylallyl diphosphate, which in turn form the basic building blocks for formation of all terpenoids. Many terpenoid compounds have useful properties and are of interest in the fields of pharmaceuticals and nutrition, and even potentially as future biofuels. The MEP pathway, its function and regulation, and the subsequent formation of terpenoids have not been fully elucidated in cyanobacteria, despite its relevance for biotechnological applications. In this review, we summarize the present knowledge about cyanobacterial terpenoid biosynthesis, both regarding the native metabolism and regarding metabolic engineering of cyanobacteria for heterologous production of non-native terpenoids.


Figure 1
Figure 1
Proposed terpenoid biosynthesis via the methylerythritol-4-phosphate (MEP) pathway in cyanobacteria. Abbreviations: Pyr: Pyruvate; GAP: glyceraldehyde 3-phosphate; DXP: 1-deoxy-d-xylulose 5-phosphate; MEP: methylerythritol-4-phosphate; CDP-ME: 4-(cytidine 5'-diphospho)-2-C-methyl-d-erythritol; CDP-MEP: 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-d-erythritol; MEcDP: 2-C-methyl-d-erythritol 2,4-cyclodiphosphate; HMBDP: 4-hydroxy-3-methylbut-2-enyldiphosphate synthase; IDP: isopentenyl diphosphate; DMADP: dimethylallyl diphosphate; GDP: geranyl diphosphate; FDP: farnesyl diphosphate; GGDP: geranylgeranyl diphosphate; DXS: 1-deoxy-d-xylulose 5-phosphate synthase; DXR: 1-deoxy-d-xylulose 5-phosphate reductoisomerase; MCT: 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase; CMK: 4-(cytidine 5'-diphospho)-2-C-methyl-d-erythritol kinase; MDS: 2-C-methyl-d-erythritol 2,4-cyclodiphosphate synthase; HDS: 4-hydroxy-3-methylbut-2-enyl diphosphate synthase; HDR: 4-hydroxy-3-methylbut-2-enyldiphosphate reductase; IDI: isopentenyl diphosphate isomerase; GDPS: geranyl diphosphate synthase; FDPS: farnesyl diphosphate synthase; GGDPS: geranylgeranyl diphosphate synthase; TPS: terpene synthase; CP450: cytochrome P450 monooxygenase.

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    1. Mazid M., Khan T., Mohammad F. Role of secondary metabolites in defense mechanisms of plants. Biol. Med. 2011;3:232–249.
    1. Tholl D. Terpene synthases and the regulation, diversity and biological roles of terpene metabolism. Curr. Opin. Plant Biol. 2006;9:297–304. doi: 10.1016/j.pbi.2006.03.014. - DOI - PubMed
    1. Van Agtmael M.A., Eggelte T.A., van Boxtel C.J. Artemisinin drugs in the treatment of malaria: From medicinal herb to registered medication. Trends Pharmacol. Sci. 1999;20:199–205. doi: 10.1016/S0165-6147(99)01302-4. - DOI - PubMed
    1. Slichenmyer W.J., von Hoff D.D. Taxol: A new and effective anti-cancer drug. Anticancer. Drugs. 1991;2:519–530. doi: 10.1097/00001813-199112000-00002. - DOI - PubMed
    1. Haridas V., Higuchi M., Jayatilake G.S., Bailey D., Mujoo K., Blake M.E., Arntzen C.J., Gutterman J.U. Avicins: Triterpenoid saponins from Acacia victoriae (Bentham) induce apoptosis by mitochondrial perturbation. Proc. Natl. Acad. Sci. USA. 2001;98:5821–5826. doi: 10.1073/pnas.101619098. - DOI - PMC - PubMed