Armochaeglobines A and B, two new indole-based alkaloids from the arthropod-derived fungus Chaetomium globosum
- PMID: 25615686
- DOI: 10.1021/ol503666b
Armochaeglobines A and B, two new indole-based alkaloids from the arthropod-derived fungus Chaetomium globosum
Abstract
Armochaeglobines A (1) and B (2), two indole-based cytochalasan alkaloids with new carbon skeletons, were obtained from the fungus Chaetomium globosum TW1-1, which was first isolated from the arthropod Armadillidium vulgare. Their structures were elucidated by extensive spectroscopic analyses, ECD calculation, and single-crystal X-ray diffraction analysis. Interestingly, compound 1 featured a unique tetracyclic 5/6/7/5 fused ring system and 2 possessed a rare 12-membered carbon scaffold.
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