Vertical bone augmentation using recombinant bone morphogenetic protein, mineralized bone allograft, and titanium mesh: a retrospective cone beam computed tomography study

Int J Oral Maxillofac Implants. Jan-Feb 2015;30(1):202-7. doi: 10.11607/jomi.3977.


Purpose: This retrospective study evaluated the use of a composite graft of recombinant human bone morphogenetic protein-2 (rhBMP-2) and particulate mineralized bone allograft protected by a titanium mesh for vertical bone augmentation.

Materials and methods: A review of data on patients from four oral and maxillofacial surgery practices in the United States who required vertical augmentation prior to implant treatment was conducted. Vertical augmentation was accomplished with rhBMP-2 in an absorbable collagen sponge (ACS) carrier and particulate allograft. Cone beam computed tomography was used to measure vertical bone gains using this technique.

Results: Sixteen vertical ridge augmentation procedures were performed in 15 patients. The maximum vertical bone gains ranged from 4.4 to 16.3 mm. The average maximum vertical bone gain was 8.53 mm. The procedure allowed implant placement in all patients. Forty implants were inserted into the grafted ridges after a minimum of 6 months of healing. All implants integrated and were used for prosthetic support.

Conclusion: This study suggests that rhBMP-2/ACS and particulate mineralized bone allograft protected by a titanium mesh offers favorable vertical bone gains to allow dental implant placement.

MeSH terms

  • Adult
  • Allografts
  • Alveolar Process / diagnostic imaging
  • Alveolar Ridge Augmentation / methods*
  • Bone Morphogenetic Protein 2 / therapeutic use*
  • Bone Substitutes / therapeutic use
  • Bone Transplantation / methods*
  • Collagen
  • Cone-Beam Computed Tomography
  • Dental Implants*
  • Female
  • Humans
  • Male
  • Mandible / diagnostic imaging
  • Mandible / surgery*
  • Maxilla / diagnostic imaging
  • Maxilla / surgery*
  • Middle Aged
  • Recombinant Proteins / therapeutic use
  • Retrospective Studies
  • Surgical Mesh*
  • Titanium / therapeutic use*
  • Transforming Growth Factor beta / therapeutic use*


  • Bone Morphogenetic Protein 2
  • Bone Substitutes
  • Dental Implants
  • Recombinant Proteins
  • Transforming Growth Factor beta
  • recombinant human bone morphogenetic protein-2
  • Collagen
  • Titanium