Combined inhalation and oral supplementation of Vitamin A and Vitamin D: a possible prevention and therapy for tuberculosis

Med Hypotheses. 2015 Mar;84(3):199-203. doi: 10.1016/j.mehy.2014.12.022. Epub 2015 Jan 10.

Abstract

Tuberculosis is continuing as a problem of mankind. With evolution, MDR and XDR forms of tuberculosis have emerged from drug sensitive strain. MDR and XDR strains are resistant to most of the antibiotics, making the management more difficult. BCG vaccine is not providing complete protection against tuberculosis. Therefore new infections are spreading at a tremendous rate. At the present moment there is experimental evidence to believe that Vitamin A and Vitamin D has anti-mycobacterial property. It is in this context, we have hypothesized a host based approach using the above vitamins that can cause possible prevention and cure of tuberculosis with minimal chance of resistance or toxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • Administration, Oral
  • Antibiotics, Antitubercular / therapeutic use*
  • Drug Combinations
  • Humans
  • Models, Biological*
  • Tuberculosis / prevention & control*
  • Vitamin A / administration & dosage
  • Vitamin A / therapeutic use*
  • Vitamin D / administration & dosage
  • Vitamin D / therapeutic use*

Substances

  • Antibiotics, Antitubercular
  • Drug Combinations
  • Vitamin A
  • Vitamin D