Comparison of mice with accelerated aging caused by distinct mechanisms

Exp Gerontol. 2015 Aug;68:43-50. doi: 10.1016/j.exger.2015.01.045. Epub 2015 Jan 21.

Abstract

Aging is the primary risk factor for numerous chronic, debilitating diseases. These diseases impact quality of life of the elderly and consume a large portion of health care costs. The cost of age-related diseases will only increase as the world's population continues to live longer. Thus it would be advantageous to consider aging itself as a therapeutic target, potentially stemming multiple age-related diseases simultaneously. While logical, this is extremely challenging as the molecular mechanisms that drive aging are still unknown. Furthermore, clinical trials to treat aging are impractical. Even in preclinical models, testing interventions to extend healthspan in old age are lengthy and therefore costly. One approach to expedite aging studies is to take advantage of mouse strains that are engineered to age rapidly. These strains are genetically and phenotypically quite diverse. This review aims to offer a comparison of several of these strains to highlight their relative strengths and weaknesses as models of mammalian and more specifically human aging. Additionally, careful identification of commonalities among the strains may lead to the identification of fundamental pathways of aging.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Aging, Premature / etiology*
  • Animals
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism
  • Cell Cycle Proteins / physiology
  • DNA Damage / physiology
  • DNA Repair / physiology
  • DNA, Mitochondrial / physiology
  • DNA-Binding Proteins / deficiency
  • DNA-Binding Proteins / physiology
  • Disease Models, Animal
  • Endonucleases / deficiency
  • Endonucleases / physiology
  • Heterozygote
  • Humans
  • Mice
  • Mitochondria / genetics
  • Mitochondria / metabolism
  • Mutation / genetics
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism
  • Protein-Serine-Threonine Kinases / physiology
  • Reactive Oxygen Species / metabolism

Substances

  • Bub1b protein, mouse
  • Cell Cycle Proteins
  • DNA, Mitochondrial
  • DNA-Binding Proteins
  • Reactive Oxygen Species
  • BUB1 protein, human
  • Protein-Serine-Threonine Kinases
  • ERCC1 protein, human
  • Endonucleases
  • Ercc1 protein, mouse