Seizing the clinical presentation in adult onset Still's disease. An extensive literature review

Neha Narula; Tathagat Narula; Andy Abril

doi:10.1016/j.autrev.2015.01.007

Seizing the clinical presentation in adult onset Still's disease. An extensive literature review

Autoimmun Rev. 2015 May;14(5):472-7. doi: 10.1016/j.autrev.2015.01.007. Epub 2015 Jan 21.

Authors

Neha Narula¹, Tathagat Narula², Andy Abril³

Affiliations

¹ Department of Rheumatology, Mayo Clinic, Jacksonville, FL, United States. Electronic address: Narula.neha@mayo.edu.
² Pulmonary Critical Care, RCCSMA, Jacksonville, FL, United States.
³ Department of Rheumatology, Mayo Clinic, Jacksonville, FL, United States.

PMID: 25617819
DOI: 10.1016/j.autrev.2015.01.007

Abstract

Adult onset Still's disease is an inflammatory disorder with a wide clinical presentation ranging from arthralgia and arthritis to rash and high-grade fever. Etiology of this rare disorder remains a mystery. We present two cases at the extreme ends of clinical presentation diagnosed with AOSD along with literature review for the same. Case one was self limiting, requiring only NSAIDS as treatment. The other was an unusual central nervous system manifestation of repeated seizures that were only responsive to pulse dose of methylprednisolone. Both met Yamaguchi criteria for adult onset Still's disease.

Keywords: Adult onset still's disease; Anakinra; Hyperferritinemia syndrome; Seizures.

Publication types

Case Reports
Review

MeSH terms

Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Female
Humans
Male
Methylprednisolone / therapeutic use
Middle Aged
Still's Disease, Adult-Onset / diagnosis*
Young Adult

Substances

Anti-Inflammatory Agents, Non-Steroidal
Methylprednisolone