AIDS-associated Kaposi's sarcoma: a molecular model for its pathogenesis

Cancer Cells. 1989 Nov;1(3):93-6.

Abstract

Kaposi's sarcoma is a mesenchymal tumor that is frequently observed in AIDS patients. Although the tumor is clearly associated with HIV-1 infection, little is known about the molecular events underlying its pathogenesis. Here we consider the potential roles of specific cytokines and the virally encoded tat product in inducing the tumor.

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications*
  • Acquired Immunodeficiency Syndrome / genetics
  • Gene Products, tat*
  • Growth Substances / genetics*
  • HIV-1 / genetics*
  • Humans
  • Models, Biological
  • Sarcoma, Kaposi / etiology*
  • Sarcoma, Kaposi / genetics
  • Trans-Activators*
  • tat Gene Products, Human Immunodeficiency Virus

Substances

  • Gene Products, tat
  • Growth Substances
  • Trans-Activators
  • tat Gene Products, Human Immunodeficiency Virus