Preparation of molecule-responsive microsized hydrogels via photopolymerization for smart microchannel microvalves

Macromol Rapid Commun. 2015 Mar;36(6):515-9. doi: 10.1002/marc.201400676. Epub 2015 Jan 26.


Microdevices designed for practical environmental pollution monitoring need to detect specific pollutants such as dioxins. Bisphenol A (BPA) has been widely used as a monomer for the synthesis of polycarbonate and epoxy resins. However, the recent discovery of its high potential ability to disrupt human endocrine systems has made the development of smart systems and microdevices for its detection and removal necessary. Molecule-responsive microsized hydrogels with β-cycrodextrin (β-CD) as ligands are prepared by photopolymerization using a fluorescence microscope. The molecule-responsive micro-hydrogels show ultra-quick shrinkage in response to target BPA. Furthermore, the flow rate of a microchannel is autonomously regulated by the molecule-responsive shrinking of their hydrogels as smart microvalves.

Keywords: dynamic cross-link; microchannels; microfluidics; molecular recognition; stimuli-responsive hydrogels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzhydryl Compounds / chemistry
  • Hydrogels / chemistry*
  • Light
  • Molecular Imprinting
  • Phenols / chemistry
  • Polymerization / radiation effects
  • Polymers / chemical synthesis
  • Polymers / chemistry*
  • beta-Cyclodextrins / chemistry*


  • Benzhydryl Compounds
  • Hydrogels
  • Phenols
  • Polymers
  • beta-Cyclodextrins
  • bisphenol A