Costs and health-related quality of life of patients with cystic fibrosis and their carers in France

J Cyst Fibros. 2015 May;14(3):384-91. doi: 10.1016/j.jcf.2014.11.006. Epub 2015 Jan 22.


Background: Our goal was to provide data on the economic burden and health-related quality of life (HRQoL) associated with cystic fibrosis (CF) in France.

Methods: A retrospective cross-sectional study was carried out on adults and children with CF, who completed an anonymous questionnaire regarding their socio-demographic characteristics, healthcare consumption and presence of a carer. Costs were calculated with a bottom-up approach, and HRQoL was assessed using EQ-5D.

Results: 82 adults and 158 children were included. The total average annual cost of CF was €29,746 per patient. Total costs were higher in adults than in children and increased with disease duration. The average utility was lower in adults (0.667 vs. 0.783 in children, p=0.0015). The HRQoL of carers was also affected (0.742 and 0.765 for carers of adults and children with CF, respectively).

Conclusions: Our study highlights the burden of CF in terms of costs and decreased HRQoL for both patients and carers.

Keywords: Costs and cost analysis; Cystic fibrosis; Economic burden; Health-related quality of life.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Cost of Illness*
  • Cross-Sectional Studies
  • Cystic Fibrosis / economics*
  • Cystic Fibrosis / epidemiology
  • Cystic Fibrosis / psychology
  • Female
  • Follow-Up Studies
  • France / epidemiology
  • Health Care Costs*
  • Hospitalization / economics
  • Humans
  • Male
  • Morbidity / trends
  • Quality of Life*
  • Retrospective Studies
  • Surveys and Questionnaires
  • Young Adult