The lymph node microenvironment and its role in the progression of metastatic cancer

Semin Cell Dev Biol. 2015 Feb:38:98-105. doi: 10.1016/j.semcdb.2015.01.008. Epub 2015 Jan 22.


Lymph nodes are initial sites for cancer metastasis in many solid tumors. However, their role in cancer progression is still not completely understood. Emerging evidence suggests that the lymph node microenvironment provides hospitable soil for the seeding and proliferation of cancer cells. Resident immune and stromal cells in the lymph node express and secrete molecules that may facilitate the survival of cancer cells in this organ. More comprehensive studies are warranted to fully understand the importance of the lymph node in tumor progression. Here, we will review the current knowledge of the role of the lymph node microenvironment in metastatic progression.

Keywords: Chemokine; Clonality; Lymph node; Lymphangiogenesis; Lymphatic vessels; Metastasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chemokines / immunology
  • Humans
  • Immune Evasion
  • Lymph Nodes / pathology*
  • Lymphatic Metastasis / pathology*
  • Monitoring, Immunologic
  • Neoplasms / immunology*
  • Neoplasms / pathology*
  • Tumor Microenvironment


  • Chemokines