Human PDGFA receptor gene maps to the same region on chromosome 4 as the KIT oncogene

Genes Chromosomes Cancer. 1989 Nov;1(2):155-8. doi: 10.1002/gcc.2870010208.


The gene for the human platelet-derived growth factor (PDGF) A type receptor was assigned to the proximal long arm of chromosome 4 by using in situ hybridization. Of 141 labeled metaphase cells, 74 had grains over chromosome 4, with a distinct peak at bands q11-q12. The presence of the gene on chromosome 4 was also confirmed by hybridization to chromosome specific libraries. This places the PDGFA receptor gene in the same region of chromosome 4 as the KIT oncogene, another member of the PDGF growth factor receptor subfamily. The two other members of this gene family, the PDGFB receptor and the colony stimulating factor-1 (CSF1) receptor, are closely linked on the distal half of the long arm of chromosome 5.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Mapping*
  • Chromosomes, Human, Pair 4*
  • Cloning, Molecular
  • DNA / genetics
  • Female
  • Humans
  • Male
  • Metaphase / genetics
  • Nucleic Acid Hybridization
  • Oncogenes / genetics*
  • Platelet-Derived Growth Factor*
  • Receptors, Cell Surface / genetics*
  • Receptors, Platelet-Derived Growth Factor


  • Platelet-Derived Growth Factor
  • Receptors, Cell Surface
  • DNA
  • Receptors, Platelet-Derived Growth Factor