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. 2015 Jan 26:4:e04586.
doi: 10.7554/eLife.04586.

Registered report: the CD47-signal regulated protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

Denise Chroscinski  1 , Nimet Maherali  2 , Erin Griner  3 ; Reproducibility Project: Cancer Biology
Affiliations

Registered report: the CD47-signal regulated protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

Denise Chroscinski et al. Elife. .

Abstract

The Willingham et al., 2012, published in PNAS in 2012. The key experiments being replicated are those reported in Figure 6A-C and Table S4. In these experiments, Willingham et al., 2012 test the safety and efficacy of anti-CD47 antibody treatment in immune competent mice utilizing a syngeneic model of mammary tumor growth in FVB mice. The Reproducibility Project: Cancer Biology is a collaboration between the eLife.

Keywords: CD47; Reproducibility Project: Cancer Biology; human biology; medicine; methodology; mouse; targeted therapy.

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Conflict of interest statement

DC: This is a Science Exchange Associated lab.

RP:CB: EI, FT and JL are employed by and hold shares in Science Exchange Inc.

The other authors declare that no competing interests exist.

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References

    1. Chan KS, Espinosa I, Chao M, Wong D, Ailles L, Diehn M, Gill H, Presti J, Jr, Chang HY, van de Rijn M, Shortliffe L, Weissman IL. Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proceedings of the National Academy of Sciences of USA. 2009;106:14016–14021. doi: 10.1073/pnas.0906549106. - DOI - PMC - PubMed
    1. Chao MP, Alizadeh AA, Tang C, Jan M, Weissman-Tsukamoto R, Zhao F, Park CY, Weissman IL, Majeti R. Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia. Cancer Research. 2010a;71:1374–1384. doi: 10.1158/0008-5472.CAN-10-2238. - DOI - PMC - PubMed
    1. Chao MP, Alizadeh AA, Tang C, Myklebust JH, Varghese B, Gill S, Jan M, Cha AC, Chan CK, Tan BT, Park CY, Zhao F, Kohrt HE, Malumbres R, Briones J, Gascoyne RD, Lossos IS, Levy R, Weissman IL, Majeti R. Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma. Cell. 2010b;142:699–713. doi: 10.1016/j.cell.2010.07.044. - DOI - PMC - PubMed
    1. Demaria S, Volm MD, Shapiro RL, Yee HT, Oratz R, Formenti SC, Muggia F, Symmans WF. Development of tumor-infiltrating lymphocytes in breast cancer after neoadjuvant paclitaxel chemotherapy. Clinical Cancer Research. 2001;7:3025–3030. - PubMed
    1. Edris B, Weiskopf K, Volkmer AK, Volkmer JP, Willingham SB, Contreras-Trujillo H, Liu J, Majeti R, West RB, Fletcher JA, Beck AH, Weissman IL, van de Rijn M. Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma. Proceedings of the National Academy of Sciences of USA. 2012;109:6656–6661. doi: 10.1073/pnas.1121629109. - DOI - PMC - PubMed

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