Hypomethylation of MAOA's first exon region in depression: a replication study

Psychiatry Res. 2015 Mar 30;226(1):389-91. doi: 10.1016/j.psychres.2015.01.003. Epub 2015 Jan 13.


We recently showed that depression in females is associated with hypomethylation in the first exon region of the monoamine oxidase A (MAOA) gene. Here we report on a small-scale (n=44) replication study of MAOA methylation which (a) confirms that female subjects with a history of depression are hypomethylated compared to controls and (b) shows that females are hypermethylated in the same region compared to males.

Keywords: DNA methylation; Epigenetics; Monoamine oxidase A.

MeSH terms

  • Brain / metabolism
  • Case-Control Studies
  • DNA Methylation / genetics*
  • Depression / genetics*
  • Depression / psychology
  • Depressive Disorder / genetics
  • Epigenesis, Genetic / genetics*
  • Exons
  • Female
  • Genetic Association Studies
  • Humans
  • Male
  • Monoamine Oxidase / genetics*
  • Promoter Regions, Genetic / genetics
  • Regression Analysis
  • Sex Characteristics


  • Monoamine Oxidase
  • monoamine oxidase A, human