The CXC chemokine receptors of fish: Insights into CXCR evolution in the vertebrates

Gen Comp Endocrinol. 2015 May 1;215:117-31. doi: 10.1016/j.ygcen.2015.01.004. Epub 2015 Jan 23.


This article will review current knowledge on CXCR in fish, that represent three distinct vertebrate groups: Agnatha (jawless fishes), Chondrichthyes (cartilaginous fishes) and Osteichthyes (bony fishes). With the sequencing of many fish genomes, information on CXCR in these species in particular has expanded considerably. In mammals, 6 CXCRs have been described, and their homologues will be initially reviewed before considering a number of atypical CXCRs and a discussion of CXCR evolution.

Keywords: CXC chemokine receptors; Evolution; Fish; Vertebrates.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Evolution*
  • Fishes / genetics*
  • Receptors, CXCR / genetics*
  • Vertebrates / genetics*


  • Receptors, CXCR