Olfactory disruption: toward controlling important insect vectors of disease

Prog Mol Biol Transl Sci. 2015:130:81-108. doi: 10.1016/bs.pmbts.2014.11.004. Epub 2014 Dec 17.

Abstract

Chemical repellents are used to decrease contacts between insect disease vectors and their hosts, thus reducing the probability of disease transmission. The molecular mechanisms by which repellents have their effects are poorly understood and remain a controversial topic. Here, we present recent results of studies aimed at a more thorough understanding of the mode of action of repellents and discuss the implications of these findings for future research and development of novel or improved repellents.

Keywords: DEET; Disease vector; Gustation; Insect; Molecular receptor; Mosquito; Olfaction; Repellent.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Control Agents*
  • Communicable Disease Control*
  • Humans
  • Insect Repellents / therapeutic use*
  • Insect Vectors / drug effects
  • Insect Vectors / physiology*
  • Olfaction Disorders / prevention & control*

Substances

  • Biological Control Agents
  • Insect Repellents