Ser/Thr phosphorylation as a regulatory mechanism in bacteria

Curr Opin Microbiol. 2015 Apr;24:47-52. doi: 10.1016/j.mib.2015.01.005. Epub 2015 Jan 24.


This review will discuss some recent work describing the role of Ser/Thr phosphorylation as a post-translational mechanism of regulation in bacteria. I will discuss the interaction between bacterial eukaryotic-like Ser/Thr kinases (eSTKs) and two-component systems as well as hints as to physiological function of eSTKs and their cognate eukaryotic-like phosphatases (eSTPs). In particular, I will highlight the role of eSTKs and eSTPs in the regulation of peptidoglycan metabolism and protein synthesis. In addition, I will discuss how data from phosphoproteomic surveys suggest that Ser/Thr phosphorylation plays a much more significant physiological role than would be predicted simply based on in vivo and in vitro analyses of individual kinases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Bacteria / metabolism*
  • Bacterial Proteins / metabolism
  • Cell Wall / metabolism
  • Gene Expression Regulation, Bacterial*
  • Phosphoric Monoester Hydrolases / metabolism
  • Phosphorylation
  • Protein-Serine-Threonine Kinases / metabolism*


  • Bacterial Proteins
  • Protein-Serine-Threonine Kinases
  • Phosphoric Monoester Hydrolases