"Potential health benefits of lunasin: a multifaceted soy-derived bioactive peptide"

J Food Sci. 2015 Mar;80(3):R485-94. doi: 10.1111/1750-3841.12786. Epub 2015 Jan 27.


Bioactive peptides are small protein fragments derived from enzymatic hydrolysis of food proteins, fermentation with proteolytic starter cultures, and gastrointestinal digestion. These peptides have positive impacts on a number of physiological functions in living beings. Lunasin, a soy-derived bioactive peptide, is one of the most promising among them. Lunasin encoded within 2S albumin (GM2S-1) gene, identified as a novel peptide extracted from soybean seed. It is composed of 43 amino acid residues with a molecular weight of 5.5 kDa. Extensive scientific studies have shown that lunasin possesses inherent antioxidative, anti-inflammatory, anticancerous properties and could also play a vital role in regulating of cholesterol biosynthesis in the body. Its high bioavailability and heat stable nature allow its potential use as dietary supplement. The present review summarizes some of the potential health and therapeutic benefits of lunasin reported hitherto.

Keywords: LDL cholesterol; anti-inflammatory; anticancerous; antioxidative; lunasin.

Publication types

  • Review

MeSH terms

  • Dietary Supplements*
  • Glycine max / chemistry*
  • Health*
  • Humans
  • Peptides / pharmacology
  • Peptides / therapeutic use*
  • Phytotherapy*
  • Seeds / chemistry*
  • Soybean Proteins / pharmacology
  • Soybean Proteins / therapeutic use*


  • GM2S-1 protein, soybean
  • Peptides
  • Soybean Proteins