Removal of anti-HLA antibodies by extracorporeal immunoadsorption to enable renal transplantation

Lancet. 1989 Jan 7;1(8628):10-2. doi: 10.1016/s0140-6736(89)91672-3.

Abstract

10 highly and persistently sensitised patients awaiting renal transplantation underwent extracorporeal immunoadsorption to remove anti-HLA antibodies. 7 patients have since received transplants. Only 1 allograft has been lost because of rejection, and there have been no serious side-effects attributable to treatment. Extracorporeal immunoadsorption may therefore be of considerable value in the management of highly sensitised patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibody Specificity
  • Cyclophosphamide / administration & dosage
  • Female
  • Graft Rejection
  • HLA Antigens / immunology*
  • Histocompatibility Testing
  • Humans
  • Immunosorbent Techniques*
  • Isoantibodies*
  • Kidney Transplantation*
  • Male
  • Middle Aged
  • Plasmapheresis
  • Prednisone / administration & dosage

Substances

  • HLA Antigens
  • Isoantibodies
  • Cyclophosphamide
  • Prednisone