In vitro anticancer activity of extracts of Mentha Spp. against human cancer cells

Indian J Biochem Biophys. 2014 Oct;51(5):416-9.

Abstract

In vitro anticancer potential of methanolic and aqueous extracts of whole plants of Mentha arvensis, M. longifolia, M. spicata and M. viridis at concentration of 100 μg/ml was evaluated against eight human cancer cell lines--A-549, COLO-205, HCT-116, MCF-7, NCI-H322, PC-3, THP-1 and U-87MG from six different origins (breast, colon, glioblastoma, lung, leukemia and prostate) using sulphorhodamine blue (SRB) assay. Methanolic extracts of above-mentioned Mentha Spp. displayed anti-proliferative effect in the range of 70-97% against four human cancer cell lines, namely COLO-205, MCF-7, NCI-H322 and THP-1; however, aqueous extracts were found to be active against HCT-116 and PC-3. The results indicate that Mentha Spp. contain certain constituents with cytotoxic properties which may find use in developing anticancer agents.

Publication types

  • Comparative Study

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Dose-Response Relationship, Drug
  • Humans
  • Mentha / chemistry*
  • Mentha / classification*
  • Neoplasms, Experimental / drug therapy*
  • Neoplasms, Experimental / pathology*
  • Phytotherapy / methods*
  • Plant Extracts / pharmacology*
  • Species Specificity

Substances

  • Antineoplastic Agents
  • Plant Extracts