[Systematic screening of masked hypertension in patients with peripheral arterial disease: a pilot study]

J Mal Vasc. 2015 Feb;40(1):10-7. doi: 10.1016/j.jmv.2014.12.008. Epub 2015 Jan 24.
[Article in French]


Aim: Masked hypertension (MH) is defined by a normal office blood pressure (BP) and a high ambulatory BP. MH is characterized by high prevalence and poor cardiovascular prognosis. The aim of this study was to evaluate the usefulness of routine MH screening, using 24-h blood pressure monitoring (BPM), among patients with peripheral arterial disease (PAD).

Methods: Between 2011 and 2013, 54 patients with PAD were included in the Hypertension and Vascular Medicine Unit of the Lille Hospital. They had normal office BP (< 140/90mmHg). A 24 h-BPM device was set on each patient. MH diagnosis was established if the BP average over 24 hours was ≥ 130/80 mmHg and/or the daytime average ≥ 135/85 mmHg and/or the nighttime average ≥ 120/70 mmHg.

Results: MH prevalence was about 42.6% (23 patients). It was significantly more frequent in diabetic patients (odds ratio: 3.8 [1.1-12.8]), in patients with known hypertension (odds ratio: 5 [1.5-16.9]) or with high normal office BP (<140/90 mmHg but ≥ 130/85 mmHg) (odds ratio: 5.6 [1.7-18.2]). By multivariate analysis, only known hypertension and high normal office BP were associated with masked hypertension.

Conclusion: The high prevalence of MH in patients with PAD shows us the importance of a careful screening of MH in this population, especially in diabetic patients, in patients with known hypertension or with a high normal office BP.

Keywords: Ambulatory blood pressure monitoring; Artériopathie oblitérante des membres inférieurs; Hypertension artérielle masquée; Masked hypertension; Mesure ambulatoire de pression artérielle; Peripheral arterial disease.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Pressure
  • Blood Pressure Monitoring, Ambulatory
  • Diabetes Complications / epidemiology
  • Diabetes Mellitus / physiopathology
  • Female
  • France / epidemiology
  • Humans
  • Male
  • Masked Hypertension / diagnosis*
  • Masked Hypertension / epidemiology
  • Mass Screening
  • Middle Aged
  • Odds Ratio
  • Peripheral Arterial Disease / complications*
  • Peripheral Arterial Disease / physiopathology*
  • Pilot Projects