Duplication, deletion, and polymorphism in the sex-determining region of the mouse Y chromosome

Science. 1989 Jan 6;243(4887):78-80. doi: 10.1126/science.2563173.


The ZFY gene in the sex-determining region of the human Y chromosome encodes a "zinc-finger" protein that may be the testis-determining factor, TDF. Although the Y chromosomes of most placental mammals carry a single homolog of ZFY, the mouse Y chromosome has two homologs, both in the sex-determining (Sxr) region. Zfy-1 alone may suffice to determine maleness; Zfy-2 is dispensable, as it was deleted in an Sxr variant that retains sex-determining function but has lost other genes. Both loci mapped near the centromere of the mouse Y chromosome. The Y chromosomes of the subspecies Mus musculus musculus and M. m. domesticus were distinguishable by a Zfy-1 restriction fragment polymorphism, which can be used to study their differing interactions with autosomal sex-determining genes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromosome Deletion*
  • Chromosome Mapping
  • Male
  • Mice
  • Mice, Inbred Strains / genetics*
  • Multigene Family*
  • Polymorphism, Genetic*
  • Polymorphism, Restriction Fragment Length
  • Sex Determination Analysis*
  • Y Chromosome*