Androgen receptor locus on the human X chromosome: regional localization to Xq11-12 and description of a DNA polymorphism

Am J Hum Genet. 1989 Feb;44(2):264-9.


The gene for the androgen receptor, mutations at which cause the X-linked androgen insensitivity syndrome, has been localized to the q11----q12 region of the human X chromosome by analysis, using a cloned cDNA for the androgen receptor, of somatic cell hybrid panels segregating portions of the X chromosome. A moderate-frequency HindIII RFLP has been found which should be useful in genetic linkage analysis of the various inherited forms of androgen insensitivity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromosome Mapping
  • Cricetinae
  • DNA Probes
  • Female
  • Genetic Linkage*
  • Genetic Markers
  • Humans
  • Hybrid Cells
  • Male
  • Mice
  • Pedigree
  • Polymorphism, Genetic*
  • Polymorphism, Restriction Fragment Length*
  • Receptors, Androgen / genetics*
  • X Chromosome*


  • DNA Probes
  • Genetic Markers
  • Receptors, Androgen