The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter

Hum Genet. 1989 Jan;81(2):171-4. doi: 10.1007/BF00293896.


The cytochrome P-450s are a large multigene family of enzymes involved in the metabolism and detoxification of drugs and chemicals. Using a full length cDNA clone for the human nifedipine oxidase gene (CYP3) and a panel of human-rodent somatic cell hybrids, we have assigned this gene family to chromosome 7q22-qter. A search for RFLPs using this probe yielded no results.

MeSH terms

  • Animals
  • Chromosome Mapping*
  • Chromosomes, Human, Pair 7*
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme System / genetics*
  • DNA / genetics
  • DNA Probes
  • Humans
  • Hybrid Cells
  • Mice
  • Mixed Function Oxygenases / genetics*
  • Multigene Family*
  • Nucleic Acid Hybridization
  • Polymorphism, Restriction Fragment Length


  • DNA Probes
  • DNA
  • Cytochrome P-450 Enzyme System
  • Mixed Function Oxygenases
  • CYP3A protein, human
  • Cytochrome P-450 CYP3A