Oral leukoplakia development in patients with pre-existing oral lichen planus

J Calif Dent Assoc. 2015 Jan;43(1):35-9.


Oral leukoplakia and oral lichen planus are conditions that have the potential to transform into squamous cell carcinoma. This article describes a series of nine patients with an initial clinical-microscopic diagnosis of lichen planus. During close follow-up, these patients developed localized areas of leukoplakia at intervals ranging from one and a half to six and a half years. While both conditions may present with white and red oral mucosal changes, their management differs with leukoplakia requiring surgical intervention, therefore accurate diagnosis is imperative.

MeSH terms

  • Biopsy
  • Follow-Up Studies
  • Humans
  • Leukoplakia, Oral / pathology*
  • Lichen Planus, Oral / pathology*
  • Mouth Mucosa / pathology
  • Precancerous Conditions / pathology
  • Risk Factors