Acyclic L-threoninol nucleic acid (L-aTNA) with suitable structural rigidity cross-pairs with DNA and RNA

Keiji Murayama; Hiromu Kashida; Hiroyuki Asanuma

doi:10.1039/c4cc09244a

Acyclic L-threoninol nucleic acid (L-aTNA) with suitable structural rigidity cross-pairs with DNA and RNA

Chem Commun (Camb). 2015 Apr 18;51(30):6500-3. doi: 10.1039/c4cc09244a.

Authors

Keiji Murayama¹, Hiromu Kashida, Hiroyuki Asanuma

Affiliation

¹ Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan. kashida@nubio.nagoya-u.ac.jp asanuma@nubio.nagoya-u.ac.jp.

PMID: 25633432
DOI: 10.1039/c4cc09244a

Abstract

We report the hybridization properties of a novel artificial nucleic acid: acyclic L-threoninol nucleic acid (L-aTNA). L-aTNA formed a more stable duplex with DNA and RNA than either D-aTNA or serinol nucleic acid (SNA) as the rigidity of the L-form was more optimal for interaction with natural nucleic acids.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Alcohols / chemistry*
Base Sequence
Butylene Glycols / chemistry*
DNA / chemistry*
DNA / genetics
Nucleic Acid Hybridization
RNA / chemistry*
RNA / genetics

Substances

Amino Alcohols
Butylene Glycols
threoninol
RNA
DNA