Mapping of the human complement factor I gene to 4q25

Genomics. 1989 Jan;4(1):82-6. doi: 10.1016/0888-7543(89)90318-2.


A detailed genetic and physical map of human complement factor I (IF) using somatic cell hybrids, in situ hybridization, and genetic linkage is reported. The gene has been localized to band 4q25. The order GC-INP10-ADH3-EGF-IF-IL2-MNS is proposed for genes on 4q on the basis of genetic and physical mapping techniques. A BclI polymorphism found with the IF probe demonstrated a maternal origin for a de novo deletion of chromosome 4 that was used in physically mapping the gene. The genetic and physical distances around band 4q24 suggest that 1 cM is approximately 1.2 million bp of DNA. This work provides a useful addition to the map of 4q.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosome Mapping
  • Chromosomes, Human, Pair 4*
  • Complement Factor I
  • Genetic Linkage
  • Humans
  • Hybrid Cells
  • Nucleic Acid Hybridization
  • Polymorphism, Restriction Fragment Length
  • Serine Endopeptidases / genetics*


  • Serine Endopeptidases
  • Complement Factor I