Regenerative medicine: targeted genome editing in vivo

Cell Res. 2015 Mar;25(3):271-2. doi: 10.1038/cr.2015.11. Epub 2015 Jan 30.


The CRISPR/Cas system has proven to be a powerful gene editing tool both in vitro and in vivo. A recent flurry of studies of in vivo gene editing using the CRISPR/Cas system bring bright prospects in creating animal models and targeted gene therapy of human genetic diseases.

Publication types

  • Comment

MeSH terms

  • Adult Stem Cells / metabolism*
  • Adult Stem Cells / transplantation*
  • Animals
  • CRISPR-Cas Systems*
  • Female
  • Infertility, Male / genetics*
  • Infertility, Male / therapy*
  • Male
  • Mutagenesis*