[Cognitive Function and Calcium. Structures and Functions of Ca2+-permeable Channels]

Clin Calcium. 2015 Feb;25(2):181-7.
[Article in Japanese]


Calcium is essential for living organisms where the increase in intracellular Ca2+ concentration functions as a second messenger for many cellular processes including synaptic transmission and neural plasticity. The cytosolic concentration of Ca2+ is finely controlled by many Ca2+-permeable ion channels and transporters. The comprehensive view of their expression, function, and regulation will advance our understanding of neural and cognitive functions of Ca2+, which leads to the future drug discovery.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Channels / metabolism*
  • Calcium Signaling / physiology*
  • Cognition / physiology*
  • Cytosol / metabolism*
  • Humans
  • Neuronal Plasticity / physiology*


  • Calcium Channels
  • Calcium